RulingRules Reference 1.7
If I’m engaged with a minion with guard, can I target that minion and the villain, as long as the minion would be…
Question
If I’m engaged with a minion with guard, can I target that minion and the villain, as long as the minion would be destroyed by the damage done by Melee?
Answer
Yes, as long as you defeat the minion with the first sentence of the ability on Melee, you may deal damage to the villain with the second sentence of the ability.
— Rules Reference 1.7